Obviously Madanna has something that appeals to the masses.  I am quite sure that perfect or not quite so perfect, this face was a big help in packaging herself as the perfect "package".

Edgar Allen Poe said that there is no beauty without strangeness.  Madonna's face is pretty close to the classic ideal of beauty, but because of this it lacks character and personality (unlike its owner).  I have seen photos of Madonna where I have struggled to work out who she is.